ACM Queue has posted my August 2012 interview on research into the hardware-software interface. We discuss the importance of a whole-stack view in addressing contemporary application security problems, which are often grounded in how we represent and execute software over lower-level substrates. We need to consider CPU design, operating systems, programming languages, applications, and formal methods — which requires building collaborations that span traditional silos in computer science research. I also consider the impact of open source on software security research methodology, and how we might extend those ideas to CPU research. A motivation for this investigation is our experimental CHERI hybrid capability processor, part of the CTSRD Project, a long-term research collaboration between the security, operating systems, and computer architecture groups at the University of Cambridge Computer Laboratory and the systems and formal methods groups SRI International Computer Science Laboratory.